cnrs  
Workshop CNRS-NSF

Biology and control theory: current challenges
April, 24-25, 2006, LAAS-CNRS, Toulouse, France
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Taking into account the current competences in the field of the classical automatic control, namely, analysis, observation and control of dynamical systems, linear, nonlinear with or without delay and/or  propagation, the main objective in organizing this manifestation is to propose a «progressive transfer» of our  «competences» towards the domains of the life sciences, and especially towards all the domains of life sciences in which a dynamic behaviour can be pointed out.

Indeed, a same molecule has different meaning and various interest of study for the specialists in the life sciences domain, depending on the type of action considered:
  • Action on isolated enzymatic systems  (biochemical);
  • Action on a dynamical chain of reaction in the alive cell (biology);
  • Action on the human organic functions (pharmacology, physiology);
  • Human therapeutic actions (medicine).
Every behaviour of a biological system with respect to one (or several) time scaling can be interpreted in a dynamical system context by using the associated tools. Indeed, we think that some knowledge in automatic control could deserve to have a better understanding of different kinds of dynamic  evolution provided that some variables of the system are measurable (or observable), even if one cannot control the object under consideration. Furthermore, we hold several tools and methods for a qualitative and quantitative analysis of such evolutions. It is worst to note that,  in biology, the notion of structure has a larger sense than in automatic control theory. More precisely, the structure defines the set of relations existing between the different elements that constitute the object or the set of objects under consideration.  Behind each structure, there is some complexity (any alive organism is strongly complex) with its own hierarchy (any alive organism is highly organized). Thus, the notion of  closed-loop exists (and is recognized like that since more than an  half century) in the context of biological systems, and from Henri Laborit « every life evolution from and after the photosynthesis has been regulated by feedback between more ordered and less ordered structures of the environmental device ».

In summary, the fact to create some links between automatic control community and that one of the life sciences could allow to address the following problems:
  • To model, observe and have a perception of the alive structures;
  • To analyze the dynamic inter-connexions into the biological systems.
The aim of the workshop is to draw with the participants of two communities in automatic control and in biology. The program will consist on the following topics:
  • Nonlinear approach for cell structure
  • vascular circulatory systems
  • Anesthesia
  • Robustness and fragility for cell structure
  • Model for some medicinal treatment
  • Dynamics of populations
  • Competition of populations
  • Simulation and Analysis tools for biology models